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ea0027oc1.2 | Oral Communications 1 | BSPED2011

Isolation and characterisation of tumorigenic progenitors/stem cells with a stabilizing mutation in β-catenin, in a mouse model of human adamantinomatous craniopharyngioma

Andoniadou Cynthia L , Gaston-Masuet Carles , LeTissier Paul , Dattani Mehul T , Martinez-Barbera Juan Pedro

Somatic stem cells of multiple tissues such as brain, blood, gut epithelium and epidermis, have specific roles in tissue homeostasis and plasticity of cell types. There is evidence that when mutated, such cells, termed cancer stem cells (CSCs) also underlie tumorigenesis, but their presence in many tumours is elusive. In the pituitary gland, somatic stem cells (PSCs) have been previously identified and characterised but little is known about their role in tumorigenesis. Adaman...

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ea0011p809 | Thyroid | ECE2006

Study of the prevalence and mechanisms of action of TSH receptor and Gs protein alfa-subunit mutations, in toxic multinodular goiter and toxic adenoma from Galicia (Spain)

Palos F , Perez O , Alvarez-Iglesias V , Cameselle J , Barreiro F , Araujo D , Argueso R , Botana M , Cabezas JM , Dominguez L , Martinez T , Nuño J , Rueda JC , Lado-Abeal J

Toxic adenomas (TA) and toxic multinodular goiters (TMNG) are frequent causes of hyperthyroidism in Galicia, an endemic goiter area. In some European countries, 4080% of toxic goiters are caused by TSH receptor (TSHr) and Gs alfa-subunit (Gsa) mutations that activate cAMP pathway.Aims: To study 1) the prevalence of TSHr and Gsa mutations in TMNG and TA from Galicia, 2) the clonality of sequenced samples, 3) the constitutive activity of the identifi...

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Endocrine Abstracts

Isolation and characterisation of tumorigenic progenitors/stem cells with a stabilizing mutation in β-catenin, in a mouse model of human adamantinomatous craniopharyngioma

Study of the prevalence and mechanisms of action of TSH receptor and Gs protein alfa-subunit mutations, in toxic multinodular goiter and toxic adenoma from Galicia (Spain)

BiosciAbstracts